expertise in collagen

Wound care management

Collagen wound dressings

The MBP product MB-Collagen Use of collagen in chronic wounds

To stimulate wound healing, collagen fleeces are used as wound dressings on non-infected burns and areas with wound healing disorders (chronic wounds). The collagen fleece accelerates and supports wound healing through its haemostatic effect and stimulates the release of various growth factors essential for wound healing such as PDGF and TGFβ by activating platelets.

MB collagen provides a matrix into which the exuding blood or wound secretion (exudate) penetrates. Platelets are activated by contact with the collagen. The now changed surface form leads to aggregation and clumping. At the same time, the release of coagulation factors is initiated, which initiates plasmatic blood coagulation, which leads to vessel occlusion with the formation of a fibrin scaffold. Haemostasis is accelerated by the platelet-activating effect of collagen.

At the same time, the wound dressing provides a capillary suction effect due to the porous structure of the collagen sponge and thus ensures the absorption of the wound secretion. The wound secretion dissolves the porous structure of the wound dressing and releases the native collagen. This has an accelerating effect on the formation of new granulation tissue in the granulation phase. In chronic wounds, the exogenous collagen binds the activity of excess metalloproteases and thereby enables the body’s own collagen synthesis, which leads to the build-up of the extracellular matrix of the granulation tissue.

The collagen supplied thus indirectly influences the regeneration and epithelisation phase by stimulating and protecting the body’s own collagen synthesis, whereby epithelisation progresses rapidly. As a competing substrate, the exogenous collagen reduces the degradation of endogenous collagen by proteases that prevent the build-up of an extracellular matrix – a prerequisite for the free mobility of cells involved in this process (e.g. leukocytes, macrophages, fibroblasts, epithelial cells) – and formation of granulation tissue.

Collagen wound dressing