expertise in collagen

Burns, Temporary Skin Replacement

Temporary Skin Replacement

The MBP product Xenoderm Collagen wound dressings as a temporary skin substitute

When collagen membranes are used as temporary biological skin substitutes (Xenoderm) to cover acute, chronic and burn wounds, they support wound healing by maintaining a moist wound environment through granulation, angiogenesis and re-epithelialisation without being integrated into the granulation tissue by cellular and vascular infiltration. They either detach from the wound when re-epithelialisation has occurred or are replaced by an autograft graft after sufficient conditioning of the wound bed.

Skin wounds close by re-epithelialisation and contraction, depending on wound location, depth, size, microbial contamination, patient health status, genetic and epigenetic factors. In non-infected, small-area wounds, which involve only the epidermis and and parts of the dermis, wound healing is primary and may result in rapid wound closure with minor scarring. Even superficial skin wounds with a largely intact dermis intact dermis can also heal primarily (e.g. split skin removal sites). Skin appendages such as hair, sebaceous and sweat glands remain intact.

Deep wounds involving the dermis and underlying layers, characterised by tissue loss, heal secondarily. The reconstruction of the damaged tissue is initiated by the formation of granulation tissue, followed by epithelialisation.

Skin appendages such as hair, sebaceous and sweat glands are not preserved. The use of skin substitutes supports granulation and creates the prerequisite for the transplantation of an autograft for re-epithelialisation if the size of the wound makes it necessary. Tertiary wound healing includes complex cases where a wound is kept open until, for example, an infection has been successfully controlled. Subsequently, wound healing is supported by plastic surgical reconstruction or suture closure. In superficial, small and clean wounds, the phases of haemostasis and inflammation extend over a shorter period of time because only small amounts of exudate are required to cleanse the wound and the blood coagulum induces rapid wound closure. In larger wounds, these phases take a longer period of time.

Temporary biological skin replacement